Osa South covers the southern portion of the Osa Peninsula and includes some of Costa Rica’s most remote coastlines, rainforest landscapes, and wildlife habitats. Bordered by Golfo Dulce, the Pacific Ocean, and Corcovado National Park, the region is recognized for its ecological significance and extensive natural areas. Large sections of the landscape remain covered by primary and secondary tropical rainforest.

The region includes destinations such as Matapalo, Carbonera, Sombrero, Tamales, Guanábana, and Zapote, each offering distinct coastal and forest environments. From surf beaches and sheltered coves to elevated ridgelines with ocean and gulf views, Osa South presents a diverse range of scenery. Rivers, wetlands, and coastal ecosystems further contribute to the area's environmental richness.

Further south toward Carate, the national highway reaches its southernmost drivable extent within Costa Rica's road network. This remote section of the peninsula is known for dense rainforest, wildlife observation, coastal lagoons, and access to trails leading into Corcovado National Park. Much of Osa South remains lightly developed, with many properties relying on independent infrastructure and maintaining a close connection to the surrounding natural environment.